4TPP

2-(3-alkoxy-1-azetidinyl) quinolines as novel PDE10A inhibitors

Summary for 4TPP

• Entry DOI: 10.2210/pdb4tpp/pdb
• Related: 4TPM
• Descriptor: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, SULFATE ION, ... (6 entities in total)
• Functional Keywords: phosphodiesterase 10a, quinolines, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: Q9Y233
• Total number of polymer chains: 2
• Total formula weight: 83468.29

Authors

Chmait, S. (deposition date: 2014-06-09, release date: 2014-12-17, Last modification date: 2023-12-27)

• Primary citation: Rzasa, R.M.,Frohn, M.J.,Andrews, K.L.,Chmait, S.,Chen, N.,Clarine, J.G.,Davis, C.,Eastwood, H.A.,Horne, D.B.,Hu, E.,Jones, A.D.,Kaller, M.R.,Kunz, R.K.,Miller, S.,Monenschein, H.,Nguyen, T.,Pickrell, A.J.,Porter, A.,Reichelt, A.,Zhao, X.,Treanor, J.J.,Allen, J.R.; Synthesis and preliminary biological evaluation of potent and selective 2-(3-alkoxy-1-azetidinyl) quinolines as novel PDE10A inhibitors with improved solubility.; Bioorg.Med.Chem., 22:6570-6585, 2014; PubMed: 25456383; DOI: 10.1016/j.bmc.2014.10.013

Experimental method

X-RAY DIFFRACTION (2.65 Å)