4TPM
Crystal structure of 2-(3-alkoxy-1-azetidinyl) quinolines as PDE10A Inhibitors
Summary for 4TPM
Entry DOI | 10.2210/pdb4tpm/pdb |
Related | 4TPP |
Descriptor | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, SULFATE ION, GLYCEROL, ... (6 entities in total) |
Functional Keywords | pde10a, quinolines, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q9Y233 |
Total number of polymer chains | 2 |
Total formula weight | 83632.34 |
Authors | Chmait, S. (deposition date: 2014-06-08, release date: 2014-12-17, Last modification date: 2023-12-27) |
Primary citation | Rzasa, R.M.,Frohn, M.J.,Andrews, K.L.,Chmait, S.,Chen, N.,Clarine, J.G.,Davis, C.,Eastwood, H.A.,Horne, D.B.,Hu, E.,Jones, A.D.,Kaller, M.R.,Kunz, R.K.,Miller, S.,Monenschein, H.,Nguyen, T.,Pickrell, A.J.,Porter, A.,Reichelt, A.,Zhao, X.,Treanor, J.J.,Allen, J.R. Synthesis and preliminary biological evaluation of potent and selective 2-(3-alkoxy-1-azetidinyl) quinolines as novel PDE10A inhibitors with improved solubility. Bioorg.Med.Chem., 22:6570-6585, 2014 Cited by PubMed: 25456383DOI: 10.1016/j.bmc.2014.10.013 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.77 Å) |
Structure validation
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