Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| A | 0007165 | biological_process | signal transduction |
| A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| B | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| B | 0007165 | biological_process | signal transduction |
| B | 0008081 | molecular_function | phosphoric diester hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 2001 |
| Chain | Residue |
| A | PHE472 |
| A | GLU473 |
| A | ASN474 |
| A | ARG510 |
| A | ARG558 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 2002 |
| Chain | Residue |
| A | ASN599 |
| A | LYS497 |
| A | LEU595 |
| A | GLY597 |
| A | HIS598 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 2003 |
| Chain | Residue |
| A | VAL512 |
| A | ARG558 |
| A | GLY559 |
| A | PHE560 |
| A | GLU685 |
| A | ALA688 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 2004 |
| Chain | Residue |
| A | LEU537 |
| A | LEU646 |
| A | ASN647 |
| A | ARG652 |
| B | LEU537 |
| B | LEU646 |
| B | ASN647 |
| B | ARG652 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 2005 |
| Chain | Residue |
| A | ARG510 |
| A | ARG511 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 2006 |
| Chain | Residue |
| A | LEU575 |
| A | TYR576 |
| A | SER577 |
| A | THR578 |
| A | GLN583 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 2007 |
| Chain | Residue |
| A | ASN508 |
| A | GLN588 |
| A | SER591 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue GOL A 2008 |
| Chain | Residue |
| A | SER650 |
| A | ARG654 |
| site_id | AC9 |
| Number of Residues | 12 |
| Details | binding site for residue 35E A 2009 |
| Chain | Residue |
| A | TYR514 |
| A | LEU665 |
| A | SER667 |
| A | THR675 |
| A | ALA679 |
| A | ILE682 |
| A | TYR683 |
| A | MET703 |
| A | GLU711 |
| A | GLY715 |
| A | GLN716 |
| A | PHE719 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 2010 |
| Chain | Residue |
| A | ASP554 |
| A | ZN2011 |
| A | HOH2123 |
| A | HOH2124 |
| A | HOH2125 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue ZN A 2011 |
| Chain | Residue |
| A | HIS519 |
| A | HIS553 |
| A | ASP554 |
| A | ASP664 |
| A | ZN2010 |
| A | HOH2122 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 2001 |
| Chain | Residue |
| B | PHE472 |
| B | GLU473 |
| B | ASN474 |
| B | ARG510 |
| B | ARG558 |
| B | HOH2101 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 2002 |
| Chain | Residue |
| B | ARG510 |
| B | ARG511 |
| B | HOH2111 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 2003 |
| Chain | Residue |
| B | PRO673 |
| B | GLY697 |
| B | ILE698 |
| B | GLN699 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 2004 |
| Chain | Residue |
| B | LYS497 |
| B | GLY597 |
| B | HIS598 |
| B | ASN599 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 2005 |
| Chain | Residue |
| A | ASN645 |
| A | ASN647 |
| B | THR539 |
| B | ASP540 |
| B | HOH2110 |
| B | HOH2125 |
| site_id | AD8 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 2006 |
| Chain | Residue |
| B | ASN508 |
| B | GLN588 |
| B | SER591 |
| site_id | AD9 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 2007 |
| Chain | Residue |
| B | PRO513 |
| B | ARG558 |
| B | GLY559 |
| B | PHE560 |
| B | GLU685 |
| B | ALA688 |
| site_id | AE1 |
| Number of Residues | 14 |
| Details | binding site for residue 35E B 2008 |
| Chain | Residue |
| B | MET703 |
| B | GLU711 |
| B | GLY715 |
| B | GLN716 |
| B | PHE719 |
| B | HOH2127 |
| B | TYR514 |
| B | LEU665 |
| B | SER667 |
| B | THR675 |
| B | ALA679 |
| B | ILE682 |
| B | TYR683 |
| B | PHE686 |
| site_id | AE2 |
| Number of Residues | 5 |
| Details | binding site for residue ZN B 2009 |
| Chain | Residue |
| B | HIS519 |
| B | HIS553 |
| B | ASP554 |
| B | ASP664 |
| B | HOH2134 |
| site_id | AE3 |
| Number of Residues | 5 |
| Details | binding site for residue ZN B 2010 |
| Chain | Residue |
| B | ASP554 |
| B | GLU582 |
| B | HOH2134 |
| B | HOH2135 |
| B | HOH2136 |
Functional Information from PROSITE/UniProt
| site_id | PS00126 |
| Number of Residues | 12 |
| Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGfsNsY |
| Chain | Residue | Details |
| A | HIS553-TYR564 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"O76083","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17389385","evidenceCode":"ECO:0000269"}]} |
