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4TKI

Crystal Structure of human Tankyrase 2 in complex with BSI-201.

Summary for 4TKI
Entry DOI10.2210/pdb4tki/pdb
Related4PML 4PNL 4PNM 4PNN 4PNQ 4PNR 4PNS 4PNT 4TJU 4TJW 4TJY 4TK0 4TK5 4TKF 4TKG
DescriptorTankyrase-2, ZINC ION, 4-iodo-3-nitrobenzamide, ... (5 entities in total)
Functional Keywordspoly(adp-ribosylation) polymerase (parp), transferase
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm: Q9H2K2
Total number of polymer chains4
Total formula weight107367.49
Authors
Qiu, W.,Lam, R.,Romanov, V.,Gordon, R.,Gebremeskel, S.,Vodsedalek, J.,Thompson, C.,Beletskaya, I.,Battaile, K.P.,Pai, E.F.,Chirgadze, N.Y. (deposition date: 2014-05-26, release date: 2014-10-15, Last modification date: 2022-10-12)
Primary citationQiu, W.,Lam, R.,Voytyuk, O.,Romanov, V.,Gordon, R.,Gebremeskel, S.,Vodsedalek, J.,Thompson, C.,Beletskaya, I.,Battaile, K.P.,Pai, E.F.,Rottapel, R.,Chirgadze, N.Y.
Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2.
Acta Crystallogr.,Sect.D, 70:2740-2753, 2014
Cited by
PubMed: 25286857
DOI: 10.1107/S1399004714017660
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.15 Å)
Structure validation

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