4TJU
Crystal Structure of human Tankyrase 2 in complex with 3,4-CPQ-5-C.
Summary for 4TJU
Entry DOI | 10.2210/pdb4tju/pdb |
Related | 4PML 4PNL 4PNM 4PNN 4PNQ 4PNR 4PNS 4PNT 4TJW 4TJY 4TK0 4TK5 4TKF 4TKG 4TKI |
Descriptor | Tankyrase-2, ZINC ION, 3-(4-CHLOROPHENYL)QUINOXALINE-5-CARBOXAMIDE, ... (4 entities in total) |
Functional Keywords | poly(adp-ribosylation) polymerase (parp), transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q9H2K2 |
Total number of polymer chains | 4 |
Total formula weight | 105341.65 |
Authors | Qiu, W.,Lam, R.,Romanov, V.,Gordon, R.,Gebremeskel, S.,Vodsedalek, J.,Thompson, C.,Beletskaya, I.,Battaile, K.P.,Pai, E.F.,Chirgadze, N.Y. (deposition date: 2014-05-25, release date: 2014-10-15, Last modification date: 2023-12-27) |
Primary citation | Qiu, W.,Lam, R.,Voytyuk, O.,Romanov, V.,Gordon, R.,Gebremeskel, S.,Vodsedalek, J.,Thompson, C.,Beletskaya, I.,Battaile, K.P.,Pai, E.F.,Rottapel, R.,Chirgadze, N.Y. Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2. Acta Crystallogr.,Sect.D, 70:2740-2753, 2014 Cited by PubMed: 25286857DOI: 10.1107/S1399004714017660 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.57 Å) |
Structure validation
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