4THN

THE CRYSTAL STRUCTURE OF ALPHA-THROMBIN-HIRUNORM IV COMPLEX REVEALS A NOVEL SPECIFICITY SITE RECOGNITION MODE.

Summary for 4THN

Entry DOI	10.2210/pdb4thn/pdb
Descriptor	ALPHA-THROMBIN, HIRUNORM IV, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	complex (serine protease-inhibitor), thrombin synthetic inhibitors, antithrombotics, hirudin-like binding mode, hirunorms, thrombin, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	37114.23
Authors	Lombardi, A.,De Simone, G.,Nastri, F.,Galdiero, S.,Della Morte, R.,Staiano, N.,Pedone, C.,Bolognesi, M.,Pavone, V. (deposition date: 1998-09-18, release date: 1999-06-15, Last modification date: 2023-08-09)
Primary citation	Lombardi, A.,De Simone, G.,Nastri, F.,Galdiero, S.,Della Morte, R.,Staiano, N.,Pedone, C.,Bolognesi, M.,Pavone, V. The crystal structure of alpha-thrombin-hirunorm IV complex reveals a novel specificity site recognition mode. Protein Sci., 8:91-95, 1999 Cited by PubMed: 10210187 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation