4S1Y

X-ray structure of human serum albumin complexed with cisplatin

Summary for 4S1Y

Entry DOI	10.2210/pdb4s1y/pdb
Related	1HK1
Descriptor	Serum albumin, Cisplatin (3 entities in total)
Functional Keywords	albumin, drug transport, fatty acids, transport protein
Biological source	Homo sapiens (human)
Cellular location	Secreted: P02768
Total number of polymer chains	1
Total formula weight	68071.44
Authors	Merlino, A. (deposition date: 2015-01-16, release date: 2015-04-29, Last modification date: 2024-10-16)
Primary citation	Ferraro, G.,Massai, L.,Messori, L.,Merlino, A. Cisplatin binding to human serum albumin: a structural study. Chem.Commun.(Camb.), 51:9436-9439, 2015 Cited by PubMed Abstract: The reaction between cisplatin and human serum albumin (HSA) was investigated by X-ray crystallography and crystal structures of the cisplatin/HSA adduct were eventually solved for the first time. Structural data unambiguously prove that cisplatin mainly binds to His105 and Met329 side chains; additional binding sites are detected at His288, Met298, and Met548 and at His535, His67 and His247. PubMed: 25873085 DOI: 10.1039/c5cc01751c PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.16 Å)

Structure validation