4S1B

Crystal Structure of L. monocytogenes phosphodiesterase PgpH HD domain in complex with Cyclic-di-AMP

Summary for 4S1B

• Entry DOI: 10.2210/pdb4s1b/pdb
• Related: 4S1C
• Descriptor: Lmo1466 protein, FE (III) ION, (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, ... (4 entities in total)
• Functional Keywords: c-di-amp, listeria monocytogenes, phosphodiesterase, hd domain, hydrolase
• Biological source: Listeria monocytogenes
• Total number of polymer chains: 2
• Total formula weight: 51785.81

Authors

Luo, S.,Tong, L. (deposition date: 2015-01-12, release date: 2015-02-11, Last modification date: 2024-02-28)

• Primary citation: Huynh, T.N.,Luo, S.,Pensinger, D.,Sauer, J.D.,Tong, L.,Woodward, J.J.; An HD-domain phosphodiesterase mediates cooperative hydrolysis of c-di-AMP to affect bacterial growth and virulence.; Proc.Natl.Acad.Sci.USA, 112:E747-E756, 2015; PubMed: 25583510; DOI: 10.1073/pnas.1416485112

Experimental method

X-RAY DIFFRACTION (2.099 Å)