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4S0T

STRUCTURE OF HUMAN PREGNANE X RECEPTOR LIGAND BINDING DOMAIN BOUND WITH ADNECTIN-1 AND COMPOUND-1

Summary for 4S0T
Entry DOI10.2210/pdb4s0t/pdb
Related4S0S 4XHD
DescriptorNuclear receptor subfamily 1 group I member 2, Adnectin-1, N-{(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl}-2-cyclopropylacetamide (3 entities in total)
Functional Keywordsnuclear receptor, multiple binding modes, xenobiotic, promiscuous, nuclear hormone receptor, transcription
Biological sourceHomo sapiens (human)
More
Cellular locationNucleus : O75469
Total number of polymer chains4
Total formula weight99754.76
Authors
Khan, J.A.,Camac, D.M. (deposition date: 2015-01-05, release date: 2015-02-04, Last modification date: 2024-02-28)
Primary citationKhan, J.A.,Camac, D.M.,Low, S.,Tebben, A.J.,Wensel, D.L.,Wright, M.C.,Su, J.,Jenny, V.,Gupta, R.D.,Ruzanov, M.,Russo, K.A.,Bell, A.,An, Y.,Bryson, J.W.,Gao, M.,Gambhire, P.,Baldwin, E.T.,Gardner, D.,Cavallaro, C.L.,Duncia, J.V.,Hynes, J.
Developing Adnectins That Target SRC Co-Activator Binding to PXR: A Structural Approach toward Understanding Promiscuity of PXR.
J.Mol.Biol., 427:924-942, 2015
Cited by
PubMed: 25579995
DOI: 10.1016/j.jmb.2014.12.022
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.14 Å)
Structure validation

217705

数据于2024-03-27公开中

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