4S0T

STRUCTURE OF HUMAN PREGNANE X RECEPTOR LIGAND BINDING DOMAIN BOUND WITH ADNECTIN-1 AND COMPOUND-1

4S0T の概要

• エントリーDOI: 10.2210/pdb4s0t/pdb
• 関連するPDBエントリー: 4S0S 4XHD
• 分子名称: Nuclear receptor subfamily 1 group I member 2, Adnectin-1, N-{(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl}-2-cyclopropylacetamide (3 entities in total)
• 機能のキーワード: nuclear receptor, multiple binding modes, xenobiotic, promiscuous, nuclear hormone receptor, transcription
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus : O75469
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 99754.76

構造登録者

Khan, J.A.,Camac, D.M. (登録日: 2015-01-05, 公開日: 2015-02-04, 最終更新日: 2024-02-28)

• 主引用文献: Khan, J.A.,Camac, D.M.,Low, S.,Tebben, A.J.,Wensel, D.L.,Wright, M.C.,Su, J.,Jenny, V.,Gupta, R.D.,Ruzanov, M.,Russo, K.A.,Bell, A.,An, Y.,Bryson, J.W.,Gao, M.,Gambhire, P.,Baldwin, E.T.,Gardner, D.,Cavallaro, C.L.,Duncia, J.V.,Hynes, J.; Developing Adnectins That Target SRC Co-Activator Binding to PXR: A Structural Approach toward Understanding Promiscuity of PXR.; J.Mol.Biol., 427:924-942, 2015; PubMed: 25579995; DOI: 10.1016/j.jmb.2014.12.022

実験手法

X-RAY DIFFRACTION (3.14 Å)