4RZW
Crystal structure of BRAF (R509H) kinase domain bound to AZ628
Summary for 4RZW
Entry DOI | 10.2210/pdb4rzw/pdb |
Related | 4RZV |
Descriptor | Serine/threonine-protein kinase B-raf, 3-(2-cyanopropan-2-yl)-N-{4-methyl-3-[(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}benzamide (2 entities in total) |
Functional Keywords | transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus : P15056 |
Total number of polymer chains | 2 |
Total formula weight | 64930.39 |
Authors | Wu, Y.,Gavathiotis, E. (deposition date: 2014-12-24, release date: 2016-08-10, Last modification date: 2023-09-20) |
Primary citation | Karoulia, Z.,Wu, Y.,Ahmed, T.A.,Qisheng, X.,Bollard, J.,Krepler, C.,Wu, X.,Zhang, C.,Bollag, G.,Herlym, M.,Fagin, J.A.,Lujambio, A.,Gavathiotis, E.,Poulikakos, P.I. An integrated model of RAF inhibitor action predicts inhibitor activity against oncogenic BRAF signaling Cancer Cell, 30:1-14, 2016 |
Experimental method | X-RAY DIFFRACTION (3.493 Å) |
Structure validation
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