4RZ1

RENIN IN COMPLEXED WITH (3S,4S)-4-({[4-methoxy-3-(3-methoxypropoxy)benzoyl](propan-2-yl)amino}methyl)pyrrolidin-3-yl benzylcarbamate INHIBITOR

4RZ1 の概要

• エントリーDOI: 10.2210/pdb4rz1/pdb
• 分子名称: Renin, 2-acetamido-2-deoxy-beta-D-glucopyranose, (3S,4S)-4-({[4-methoxy-3-(3-methoxypropoxy)benzoyl](propan-2-yl)amino}methyl)pyrrolidin-3-yl benzylcarbamate, ... (6 entities in total)
• 機能のキーワード: hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens
• 細胞内の位置: Secreted: P00797
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 76256.01

構造登録者

Ostermann, N. (登録日: 2014-12-18, 公開日: 2015-03-25, 最終更新日: 2020-07-29)

• 主引用文献: Sellner, H.,Cottens, S.,Cumin, F.,Ehrhardt, C.,Kosaka, T.,Lorthiois, E.,Ostermann, N.,Webb, R.L.,Rigel, D.F.,Wagner, T.,Maibaum, J.; trans-3,4-Disubstituted pyrrolidines as inhibitors of the human aspartyl protease renin. Part II: Prime site exploration using an oxygen linker.; Bioorg.Med.Chem.Lett., 25:1787-1791, 2015; PubMed: 25754490; DOI: 10.1016/j.bmcl.2015.02.040

実験手法

X-RAY DIFFRACTION (2.6 Å)