4RXE
T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-14
Summary for 4RXE
Entry DOI | 10.2210/pdb4rxe/pdb |
Descriptor | Farnesyl pyrophosphate synthase, {[(3-methylpyridin-2-yl)amino]methanediyl}bis(phosphonic acid), MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Trypanosoma brucei |
Total number of polymer chains | 2 |
Total formula weight | 89661.56 |
Authors | Cao, R.,Liu, Y.-L.,Oldfield, E. (deposition date: 2014-12-10, release date: 2015-04-15, Last modification date: 2023-09-20) |
Primary citation | Liu, Y.L.,Cao, R.,Wang, Y.,Oldfield, E. Farnesyl diphosphate synthase inhibitors with unique ligand-binding geometries. ACS Med Chem Lett, 6:349-354, 2015 Cited by PubMed: 25815158DOI: 10.1021/ml500528x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
Download full validation report