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4RX5

Bruton's tyrosine kinase (BTK) with pyridazinone compound 23

Summary for 4RX5
Entry DOI10.2210/pdb4rx5/pdb
DescriptorTyrosine-protein kinase BTK, SULFATE ION, GLYCEROL, ... (6 entities in total)
Functional Keywordsprotein kinase, phosphotransfer catalyst, transferase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: Q06187
Total number of polymer chains1
Total formula weight32814.64
Authors
Eigenbrot, C.,Yu, C. (deposition date: 2014-12-08, release date: 2015-12-02, Last modification date: 2023-09-20)
Primary citationYoung, W.B.,Barbosa, J.,Blomgren, P.,Bremer, M.C.,Crawford, J.J.,Dambach, D.,Eigenbrot, C.,Gallion, S.,Johnson, A.R.,Kropf, J.E.,Lee, S.H.,Liu, L.,Lubach, J.W.,Macaluso, J.,Maciejewski, P.,Mitchell, S.A.,Ortwine, D.F.,Di Paolo, J.,Reif, K.,Scheerens, H.,Schmitt, A.,Wang, X.,Wong, H.,Xiong, J.M.,Xu, J.,Yu, C.,Zhao, Z.,Currie, K.S.
Discovery of highly potent and selective Bruton's tyrosine kinase inhibitors: Pyridazinone analogs with improved metabolic stability.
Bioorg.Med.Chem.Lett., 26:575-579, 2016
Cited by
PubMed: 26675441
DOI: 10.1016/j.bmcl.2015.11.076
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.356 Å)
Structure validation

217705

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