4RWS

Crystal structure of CXCR4 and viral chemokine antagonist vMIP-II complex (PSI Community Target)

Summary for 4RWS

Entry DOI	10.2210/pdb4rws/pdb
Related	3ODU 3OE0 3OE6 3OE8 3OE9
Descriptor	C-X-C chemokine receptor type 4/Endolysin chimeric protein, Viral macrophage inflammatory protein 2 (2 entities in total)
Functional Keywords	human chemokine-chemokine receptor complex, gpcr signaling, psi-biology, gpcr network, membrane protein, gpcr, cxcr4, viral antagonist chemokine vmip-ii, membrane, lipidic cubic phase, t4l, structural genomics, signaling protein, hydrolase
Biological source	Homo sapiens More
Cellular location	Cell membrane; Multi-pass membrane protein: P61073 Secreted: Q98157
Total number of polymer chains	2
Total formula weight	65746.21
Authors	Qin, L.,Kufareva, I.,Holden, L.,Wang, C.,Zheng, Y.,Wu, H.,Fenalti, G.,Han, G.W.,Cherezov, V.,Abagyan, R.,Stevens, R.C.,Handel, T.M.,GPCR Network (GPCR) (deposition date: 2014-12-05, release date: 2015-02-11, Last modification date: 2023-09-20)
Primary citation	Qin, L.,Kufareva, I.,Holden, L.G.,Wang, C.,Zheng, Y.,Zhao, C.,Fenalti, G.,Wu, H.,Han, G.W.,Cherezov, V.,Abagyan, R.,Stevens, R.C.,Handel, T.M. Structural biology. Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine. Science, 347:1117-1122, 2015 Cited by PubMed: 25612609 DOI: 10.1126/science.1261064 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1 Å)

Structure validation