4RWS

Crystal structure of CXCR4 and viral chemokine antagonist vMIP-II complex (PSI Community Target)

4RWS の概要

• エントリーDOI: 10.2210/pdb4rws/pdb
• 関連するPDBエントリー: 3ODU 3OE0 3OE6 3OE8 3OE9
• 分子名称: C-X-C chemokine receptor type 4/Endolysin chimeric protein, Viral macrophage inflammatory protein 2 (2 entities in total)
• 機能のキーワード: human chemokine-chemokine receptor complex, gpcr signaling, psi-biology, gpcr network, membrane protein, gpcr, cxcr4, viral antagonist chemokine vmip-ii, membrane, lipidic cubic phase, t4l, structural genomics, signaling protein, hydrolase
• 由来する生物種: Homo sapiens; 詳細
• 細胞内の位置: Cell membrane; Multi-pass membrane protein: P61073; Secreted: Q98157
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 65746.21

構造登録者

Qin, L.,Kufareva, I.,Holden, L.,Wang, C.,Zheng, Y.,Wu, H.,Fenalti, G.,Han, G.W.,Cherezov, V.,Abagyan, R.,Stevens, R.C.,Handel, T.M.,GPCR Network (GPCR) (登録日: 2014-12-05, 公開日: 2015-02-11, 最終更新日: 2023-09-20)

• 主引用文献: Qin, L.,Kufareva, I.,Holden, L.G.,Wang, C.,Zheng, Y.,Zhao, C.,Fenalti, G.,Wu, H.,Han, G.W.,Cherezov, V.,Abagyan, R.,Stevens, R.C.,Handel, T.M.; Structural biology. Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine.; Science, 347:1117-1122, 2015; PubMed: 25612609; DOI: 10.1126/science.1261064

実験手法

X-RAY DIFFRACTION (3.1 Å)