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4RVT

MAP4K4 in complex with a pyridin-2(1H)-one derivative

Summary for 4RVT
Entry DOI10.2210/pdb4rvt/pdb
DescriptorMitogen-activated protein kinase kinase kinase kinase 4, 3-hexanoyl-4-hydroxy-5-(4-hydroxyphenyl)pyridin-2(1H)-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (4 entities in total)
Functional Keywordspyridin-2(1h)-one ligand, type i, dfg-in, serine/threonine kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm : O95819
Total number of polymer chains2
Total formula weight75568.34
Authors
Richters, A.,Becker, C.,Kleine, S.,Rauh, D. (deposition date: 2014-11-27, release date: 2015-05-27, Last modification date: 2023-09-20)
Primary citationSchroder, P.,Forster, T.,Kleine, S.,Becker, C.,Richters, A.,Ziegler, S.,Rauh, D.,Kumar, K.,Waldmann, H.
Neuritogenic Militarinone-Inspired 4-Hydroxypyridones Target the Stress Pathway Kinase MAP4K4.
Angew.Chem.Int.Ed.Engl., 54:12398-12403, 2015
Cited by
PubMed: 25908259
DOI: 10.1002/anie.201501515
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

217705

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