4RVT
MAP4K4 in complex with a pyridin-2(1H)-one derivative
Summary for 4RVT
Entry DOI | 10.2210/pdb4rvt/pdb |
Descriptor | Mitogen-activated protein kinase kinase kinase kinase 4, 3-hexanoyl-4-hydroxy-5-(4-hydroxyphenyl)pyridin-2(1H)-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (4 entities in total) |
Functional Keywords | pyridin-2(1h)-one ligand, type i, dfg-in, serine/threonine kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : O95819 |
Total number of polymer chains | 2 |
Total formula weight | 75568.34 |
Authors | Richters, A.,Becker, C.,Kleine, S.,Rauh, D. (deposition date: 2014-11-27, release date: 2015-05-27, Last modification date: 2023-09-20) |
Primary citation | Schroder, P.,Forster, T.,Kleine, S.,Becker, C.,Richters, A.,Ziegler, S.,Rauh, D.,Kumar, K.,Waldmann, H. Neuritogenic Militarinone-Inspired 4-Hydroxypyridones Target the Stress Pathway Kinase MAP4K4. Angew.Chem.Int.Ed.Engl., 54:12398-12403, 2015 Cited by PubMed: 25908259DOI: 10.1002/anie.201501515 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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