4RV8

Co-Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Cryptosporidium parvum and the inhibitor p131

Summary for 4RV8

• Entry DOI: 10.2210/pdb4rv8/pdb
• Related: 3FFS 4IXH
• Descriptor: Inosine-5'-monophosphate dehydrogenase, INOSINIC ACID, 1-(2-{3-[(1E)-N-(2-aminoethoxy)ethanimidoyl]phenyl}propan-2-yl)-3-(4-chloro-3-nitrophenyl)urea, ... (6 entities in total)
• Functional Keywords: structural genomics, niaid, national institute of allergy and infectious diseases, center for structural genomics of infectious diseases, csgid, alpha-beta fold, tim barrel, oxidoreductase
• Biological source: Cryptosporidium parvum; More
• Cellular location: Cytoplasm : Q8T6T2
• Total number of polymer chains: 4
• Total formula weight: 157926.68

Authors

Kim, Y.,Makowska-Grzyska, M.,Gu, M.,Kavitha, M.,Hedstrom, L.,Anderson, W.F.,Joachimiak, A.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2014-11-25, release date: 2014-12-31, Last modification date: 2023-12-06)

• Primary citation: Kim, Y.,Makowska-Grzyska, M.,Gorla, S.K.,Gollapalli, D.R.,Cuny, G.D.,Joachimiak, A.,Hedstrom, L.; Structure of Cryptosporidium IMP dehydrogenase bound to an inhibitor with in vivo antiparasitic activity.; Acta Crystallogr F Struct Biol Commun, 71:531-538, 2015; PubMed: 25945705; DOI: 10.1107/S2053230X15000187

Experimental method

X-RAY DIFFRACTION (2.053 Å)