4RUR
Yeast 20S proteasome in complex with the alkaloid indolo-phakellin (4)
Summary for 4RUR
Entry DOI | 10.2210/pdb4rur/pdb |
Related | 1RYP |
Descriptor | Proteasome subunit alpha type-2, Proteasome subunit beta type-4, Proteasome subunit beta type-5, ... (17 entities in total) |
Functional Keywords | proteasome, alkaloid, reversible inhibition, drug discovery, halogen bonding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Saccharomyces cerevisiae S288c (Baker's yeast) More |
Cellular location | Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451 |
Total number of polymer chains | 28 |
Total formula weight | 731989.93 |
Authors | Beck, P.,Lansdell, T.A.,Hewlett, N.M.,Tepe, J.J.,Groll, M. (deposition date: 2014-11-21, release date: 2014-12-10, Last modification date: 2023-09-20) |
Primary citation | Beck, P.,Lansdell, T.A.,Hewlett, N.M.,Tepe, J.J.,Groll, M. Indolo-Phakellins as beta 5-Specific Noncovalent Proteasome Inhibitors. Angew.Chem.Int.Ed.Engl., 54:2830-2833, 2015 Cited by PubMed: 25581903DOI: 10.1002/anie.201410168 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
Download full validation report