4RUC

Crystal structure of Y-family DNA polymerase Dpo4 extending from a MeFapy-dG:dC pair

4RUC の概要

• エントリーDOI: 10.2210/pdb4ruc/pdb
• 関連するPDBエントリー: 4RU9 4RUA
• 分子名称: DNA polymerase IV, Nucleic acids Template: TCAT(MF7)TAATCCTTCCCCC, Nucleic acids Primar: GGGGGAAGGATTAC, ... (6 entities in total)
• 機能のキーワード: protein, dna, dna damage, dna-directed dna polymerase, adenosine triphosphate, y-family polymerase, trans-lesion synthesis (tls), dna binding, mefapy-dg lesion bypass, primer extension, 2, 6-diamino-4-hydroxy n(5)-(methyl)-formamidopyrimidine (mefapy-dg) lesion, transferase-dna complex, transferase/dna
• 由来する生物種: Sulfolobus solfataricus P2; 詳細
• 細胞内の位置: Cytoplasm : Q97W02
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 49435.34

構造登録者

Patra, A.,Banerjee, S.,Stone, M.P.,Egli, M. (登録日: 2014-11-18, 公開日: 2015-08-05, 最終更新日: 2024-02-28)

• 主引用文献: Patra, A.,Banerjee, S.,Johnson Salyard, T.L.,Malik, C.K.,Christov, P.P.,Rizzo, C.J.,Stone, M.P.,Egli, M.; Structural Basis for Error-Free Bypass of the 5-N-Methylformamidopyrimidine-dG Lesion by Human DNA Polymerase eta and Sulfolobus solfataricus P2 Polymerase IV.; J.Am.Chem.Soc., 137:7011-7014, 2015; PubMed: 25988947; DOI: 10.1021/jacs.5b02701

実験手法

X-RAY DIFFRACTION (2.9 Å)