4RSZ

The X-ray structure of the Primary Adduct formed in the Reaction between Cisplatin and Cytochrome c

4RSZ の概要

• エントリーDOI: 10.2210/pdb4rsz/pdb
• 分子名称: Cytochrome c, HEME C, Cisplatin, ... (6 entities in total)
• 機能のキーワード: electron transport
• 由来する生物種: Equus caballus (domestic horse,equine)
• 細胞内の位置: Mitochondrion intermembrane space: P00004
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 76749.04

構造登録者

Merlino, A. (登録日: 2014-11-12, 公開日: 2015-01-14, 最終更新日: 2024-10-30)

主引用文献

Ferraro, G.,Messori, L.,Merlino, A.
The X-ray structure of the primary adducts formed in the reaction between cisplatin and cytochrome c.
Chem.Commun.(Camb.), 51:2559-2561, 2015

PubMed Abstract: In the present study, the interactions between cisplatin and cytochrome c are investigated. Based on high-resolution X-ray diffraction data, two monometalated species, i.e. cyt c-Pt(NH3)2 and cyt c-Pt(NH3)2Cl, are found to be the main adducts that form in the reaction between the protein and the drug. Both monodentate and bidentate platinum coordination to the protein is observed, with platinum binding either to Met65 or to Met65 and Glu61, simultaneously.

PubMed: 25567806
DOI: 10.1039/c4cc09056j

実験手法

X-RAY DIFFRACTION (2.19 Å)