4RSV

Human Obscurin Ig58 Domain

Summary for 4RSV

• Entry DOI: 10.2210/pdb4rsv/pdb
• Related: 2MWC
• Descriptor: Obscurin (2 entities in total)
• Functional Keywords: ig-like, cytoskeletal, titin, myocytes, structural protein
• Biological source: Homo sapiens (human)
• Cellular location: Isoform 3: Cytoplasm, myofibril, sarcomere, M line : Q5VST9
• Total number of polymer chains: 1
• Total formula weight: 11423.82

Authors

Wright, N.T.,Oehler, M.C.,Berndsen, C.E.,Du Pont, K.E. (deposition date: 2014-11-11, release date: 2016-02-24, Last modification date: 2023-09-20)

• Primary citation: Hu, L.Y.R.,Ackermann, M.A.,Hecker, P.A.,Prosser, B.L.,King, B.,O'Connell, K.A.,Asico, L.D.,Jose, P.A.,Wright, N.T.,Oehler, M.C.,Berndsen, C.E.,Du Pont, K.E.,Meyer, L.C.,Lederer, W.J.,Kontrogianni-Konstantopoulos, A.; Arrhythmia and deregulated Ca2+ cycling underlie the development of hypertrophic cardiomyopathy due to mutant giant obscurin; To be Published,

Experimental method

X-RAY DIFFRACTION (2.41 Å)