4RS1

Crystal structure of receptor-cytokine complex

4RS1 の概要

• エントリーDOI: 10.2210/pdb4rs1/pdb
• 分子名称: Granulocyte-macrophage colony-stimulating factor receptor subunit alpha, Granulocyte-macrophage colony-stimulating factor, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: cytokine, receptor, cytokine receptor-cytokine complex, cytokine receptor/cytokine
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 46278.27

構造登録者

Broughton, S.E.,Parker, M.W.,Dhagat, U. (登録日: 2014-11-06, 公開日: 2015-11-11, 最終更新日: 2020-07-29)

• 主引用文献: Broughton, S.E.,Hercus, T.R.,Nero, T.L.,Dottore, M.,McClure, B.J.,Dhagat, U.,Taing, H.,Gorman, M.A.,King-Scott, J.,Lopez, A.F.,Parker, M.W.; Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling.; Structure, 24:1271-1281, 2016; PubMed: 27396825; DOI: 10.1016/j.str.2016.05.017

実験手法

X-RAY DIFFRACTION (2.68 Å)