4RS0

Crystal Structure of Murine H90W Cyclooxygenase-2 Complexed with S-ibuprofen

4RS0 の概要

• エントリーDOI: 10.2210/pdb4rs0/pdb
• 関連するPDBエントリー: 4RRW 4RRX 4RRY 4RRZ
• 分子名称: Prostaglandin G/H synthase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, octyl beta-D-glucopyranoside, ... (6 entities in total)
• 機能のキーワード: nsaid, protein-drug complex, prostaglandin-endoperoxide synthase, glycosylation, membrane, oxidoreductase
• 由来する生物種: Mus musculus (mouse)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 68746.24

構造登録者

Xu, S.,Blobaum, A.L.,Banerjee, S.,Marnett, L.J. (登録日: 2014-11-06, 公開日: 2015-04-08, 最終更新日: 2023-09-20)

• 主引用文献: Blobaum, A.L.,Xu, S.,Rowlinson, S.W.,Duggan, K.C.,Banerjee, S.,Kudalkar, S.N.,Birmingham, W.R.,Ghebreselasie, K.,Marnett, L.J.; Action at a Distance: MUTATIONS OF PERIPHERAL RESIDUES TRANSFORM RAPID REVERSIBLE INHIBITORS TO SLOW, TIGHT BINDERS OF CYCLOOXYGENASE-2.; J.Biol.Chem., 290:12793-12803, 2015; PubMed: 25825493; DOI: 10.1074/jbc.M114.635987

実験手法

X-RAY DIFFRACTION (2.807 Å)