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4RS0

Crystal Structure of Murine H90W Cyclooxygenase-2 Complexed with S-ibuprofen

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1AProstaglandin G/H synthase 2polymer58767380.81UniProt (Q05769)
Pfam (PF00008)
Pfam (PF03098)
In PDB
Mus musculus (mouse)Cyclooxygenase-2, COX-2, Glucocorticoid-regulated inflammatory cyclooxygenase, Gripghs, Macrophage activation-associated marker protein P71/73, PES-2, PHS II, Prostaglandin H2 synthase 2, PGH synthase 2, PGHS-2, Prostaglandin-endoperoxide synthase 2, TIS10 protein
2B2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched424.41In PDB
GlyTouCan (G42666HT)
3Aoctyl beta-D-glucopyranosidenon-polymer292.41Chemie (BOG)
4A2-acetamido-2-deoxy-beta-D-glucopyranosenon-polymer221.22Chemie (NAG)
5AIBUPROFENnon-polymer206.31Chemie (IBP)
6waterwater18.0108Chemie (HOH)
Sequence modifications
A: 33 - 618 (UniProt: Q05769)
PDBExternal DatabaseDetails
Trp 90His 75engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight67380.8
BranchedNumber of molecules1
Total formula weight424.4
Non-Polymers*Number of molecules4
Total formula weight941.1
All*Total formula weight68746.2
*Water molecules are not included.

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PDB entries from 2024-03-27

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