4RRY

Crystal Structure of Apo Murine H90W Cyclooxygenase-2

Summary for 4RRY

Entry DOI	10.2210/pdb4rry/pdb
Related	4RRW 4RRX 4RRZ 4RS0
Descriptor	Prostaglandin G/H synthase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	prostaglandin-endoperoxide synthase, glycosylation, membrane, oxidoreductase
Biological source	Mus musculus (mouse)
Total number of polymer chains	4
Total formula weight	274744.57
Authors	Xu, S.,Blobaum, A.L.,Banerjee, S.,Marnett, L.J. (deposition date: 2014-11-06, release date: 2015-04-08, Last modification date: 2023-09-20)
Primary citation	Blobaum, A.L.,Xu, S.,Rowlinson, S.W.,Duggan, K.C.,Banerjee, S.,Kudalkar, S.N.,Birmingham, W.R.,Ghebreselasie, K.,Marnett, L.J. Action at a Distance: MUTATIONS OF PERIPHERAL RESIDUES TRANSFORM RAPID REVERSIBLE INHIBITORS TO SLOW, TIGHT BINDERS OF CYCLOOXYGENASE-2. J.Biol.Chem., 290:12793-12803, 2015 Cited by PubMed: 25825493 DOI: 10.1074/jbc.M114.635987 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.429 Å)

Structure validation