4RP6
Structure of the amyloid-forming segment LTIITLE from p53 (residues 252-258)
Summary for 4RP6
Entry DOI | 10.2210/pdb4rp6/pdb |
Related | 4RP7 |
Descriptor | LTIITLE heptapeptide segment from p53 (2 entities in total) |
Functional Keywords | p53, amyloid, fibril, amyloid-like protofibril, p53 aggregates, polymer, transcription factor, oncogene, cancer, p53 mutant, protein fibril |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637 |
Total number of polymer chains | 1 |
Total formula weight | 801.97 |
Authors | Soriaga, A.B.,Soragni, A.,Eisenberg, D. (deposition date: 2014-10-29, release date: 2016-01-13, Last modification date: 2024-02-28) |
Primary citation | Soragni, A.,Janzen, D.M.,Johnson, L.M.,Lindgren, A.G.,Thai-Quynh Nguyen, A.,Tiourin, E.,Soriaga, A.B.,Lu, J.,Jiang, L.,Faull, K.F.,Pellegrini, M.,Memarzadeh, S.,Eisenberg, D.S. A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas. Cancer Cell, 29:90-103, 2016 Cited by PubMed: 26748848DOI: 10.1016/j.ccell.2015.12.002 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.703 Å) |
Structure validation
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