4RN4

Human Carbonic anhydrases II in complex with a acetazolamide derivative comprising one hydrophobic and one hydrophilic tail moiety

Summary for 4RN4

Entry DOI	10.2210/pdb4rn4/pdb
Descriptor	Carbonic anhydrase 2, ZINC ION, FORMIC ACID, ... (6 entities in total)
Functional Keywords	carbonic anhydrase, acetazolamide, lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm : P00918
Total number of polymer chains	1
Total formula weight	30073.19
Authors	Ren, B.,Tanpure, R.,Peat, T.S.,Bornaghi, L.F.,Vullo, D.,Supuran, C.T.,Poulsen, S. (deposition date: 2014-10-22, release date: 2015-01-28, Last modification date: 2024-02-28)
Primary citation	Tanpure, R.P.,Ren, B.,Peat, T.S.,Bornaghi, L.F.,Vullo, D.,Supuran, C.T.,Poulsen, S.A. Carbonic anhydrase inhibitors with dual-tail moieties to match the hydrophobic and hydrophilic halves of the carbonic anhydrase active site. J.Med.Chem., 58:1494-1501, 2015 Cited by PubMed: 25581127 DOI: 10.1021/jm501798g PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.53 Å)

Structure validation