4RMZ

Crystal Structure of IRAK-4

Summary for 4RMZ

• Entry DOI: 10.2210/pdb4rmz/pdb
• Related: 2NRU 2NRY
• Descriptor: Interleukin-1 receptor-associated kinase 4, 3-nitro-N-[1-phenyl-5-(piperidin-1-ylmethyl)-1H-benzimidazol-2-yl]benzamide (3 entities in total)
• Functional Keywords: serine/threonine protein kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm : Q9NWZ3
• Total number of polymer chains: 2
• Total formula weight: 70226.89

Authors

Johnstone, S.,Sudom, A.,Liu, J.,Walker, N.P.,Wang, Z. (deposition date: 2014-10-22, release date: 2016-01-13, Last modification date: 2016-03-23)

• Primary citation: Johnstone, S.,Sudom, A.,Liu, J.,Walker, N.P.,Wang, Z.; Crystal structures of IRAK-4 kinase in complex with inhibitors: a serine/threonine kinase with tyrosine as a gatekeeper; To be Published,

Experimental method

X-RAY DIFFRACTION (2.2 Å)