4RJD
TFP bound in alternate orientations to calcium-saturated Calmodulin C-Domains
Summary for 4RJD
Entry DOI | 10.2210/pdb4rjd/pdb |
Related | 1A29 1CTR 1LIN |
Descriptor | Calmodulin, CALCIUM ION, 10-[3-(4-METHYL-PIPERAZIN-1-YL)-PROPYL]-2-TRIFLUOROMETHYL-10H-PHENOTHIAZINE, ... (8 entities in total) |
Functional Keywords | anti-psychotic, antagonist, ca2+ binding, central nervous system, trifluoromethyl, promiscuous binding, tfp-binding, calcium-binding protein |
Biological source | Rattus norvegicus (brown rat,rat,rats) |
Total number of polymer chains | 2 |
Total formula weight | 17462.16 |
Authors | Feldkamp, M.D.,Gakhar, L.,Pandey, N.,Shea, M.A. (deposition date: 2014-10-08, release date: 2015-08-26, Last modification date: 2023-09-20) |
Primary citation | Feldkamp, M.D.,Gakhar, L.,Pandey, N.,Shea, M.A. Opposing orientations of the anti-psychotic drug trifluoperazine selected by alternate conformations of M144 in calmodulin. Proteins, 83:989-996, 2015 Cited by PubMed: 25694384DOI: 10.1002/prot.24781 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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