4RJD

TFP bound in alternate orientations to calcium-saturated Calmodulin C-Domains

4RJD の概要

• エントリーDOI: 10.2210/pdb4rjd/pdb
• 関連するPDBエントリー: 1A29 1CTR 1LIN
• 分子名称: Calmodulin, CALCIUM ION, 10-[3-(4-METHYL-PIPERAZIN-1-YL)-PROPYL]-2-TRIFLUOROMETHYL-10H-PHENOTHIAZINE, ... (8 entities in total)
• 機能のキーワード: anti-psychotic, antagonist, ca2+ binding, central nervous system, trifluoromethyl, promiscuous binding, tfp-binding, calcium-binding protein
• 由来する生物種: Rattus norvegicus (brown rat,rat,rats)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 17462.16

構造登録者

Feldkamp, M.D.,Gakhar, L.,Pandey, N.,Shea, M.A. (登録日: 2014-10-08, 公開日: 2015-08-26, 最終更新日: 2023-09-20)

• 主引用文献: Feldkamp, M.D.,Gakhar, L.,Pandey, N.,Shea, M.A.; Opposing orientations of the anti-psychotic drug trifluoperazine selected by alternate conformations of M144 in calmodulin.; Proteins, 83:989-996, 2015; PubMed: 25694384; DOI: 10.1002/prot.24781

実験手法

X-RAY DIFFRACTION (2 Å)