4RIY

Crystal structure of an EGFR/HER3 kinase domain heterodimer containing the cancer-associated HER3-E909G mutation

4RIY の概要

• エントリーDOI: 10.2210/pdb4riy/pdb
• 関連するPDBエントリー: 4RIW 4RIX
• 分子名称: Receptor tyrosine-protein kinase erbB-3, Epidermal growth factor receptor, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (5 entities in total)
• 機能のキーワード: receptor tyrosine kinase, pseudokinase, kinase, atp binding, membrane, transferase
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P21860; Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 153134.62

構造登録者

Littlefield, P.,Liu, L.,Jura, N. (登録日: 2014-10-07, 公開日: 2014-12-10, 最終更新日: 2023-09-20)

• 主引用文献: Littlefield, P.,Liu, L.,Mysore, V.,Shan, Y.,Shaw, D.E.,Jura, N.; Structural analysis of the EGFR/HER3 heterodimer reveals the molecular basis for activating HER3 mutations.; Sci.Signal., 7:ra114-ra114, 2014; PubMed: 25468994; DOI: 10.1126/scisignal.2005786

実験手法

X-RAY DIFFRACTION (2.981 Å)