4RFW
Crystal structure of human retinoid X Receptor alpha-ligand binding domain complex with 9cUAB70 and the coactivator peptide GRIP-1
Summary for 4RFW
Entry DOI | 10.2210/pdb4rfw/pdb |
Related | 3OAP 4K4J |
Descriptor | Retinoic acid receptor RXR-alpha, Nuclear receptor coactivator 2, (2E,4E,6Z,8E)-3,7-dimethyl-8-(6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ylidene)octa-2,4,6-trienoic acid, ... (4 entities in total) |
Functional Keywords | ligand binding domain, cancer prevention, coactivator peptide, conformationally constrained retinoids, transcription |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus : P19793 Q15596 |
Total number of polymer chains | 2 |
Total formula weight | 27785.30 |
Authors | Xia, G.,Muccio, D.D.,Smith, C.D. (deposition date: 2014-09-28, release date: 2015-09-16, Last modification date: 2023-09-20) |
Primary citation | Atigadda, V.R.,Xia, G.,Deshpande, A.,Wu, L.,Kedishvili, N.,Smith, C.D.,Krontiras, H.,Bland, K.I.,Grubbs, C.J.,Brouillette, W.J.,Muccio, D.D. Conformationally Defined Rexinoids and Their Efficacy in the Prevention of Mammary Cancers. J.Med.Chem., 58:7763-7774, 2015 Cited by PubMed: 26331194DOI: 10.1021/acs.jmedchem.5b00829 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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