4RFR
Complex structure of AlkB/rhein
Summary for 4RFR
Entry DOI | 10.2210/pdb4rfr/pdb |
Related | 3T4H |
Descriptor | Alpha-ketoglutarate-dependent dioxygenase AlkB, 4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid, MANGANESE (II) ION, ... (4 entities in total) |
Functional Keywords | protein-inhibitor complex, demethylation, alkb family, jellyroll fold, demethylase, nucleic acid binding, nucleus, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor |
Biological source | Escherichia coli |
Total number of polymer chains | 1 |
Total formula weight | 22895.95 |
Authors | Li, Q.,Huang, Y.,Li, J.F.,Yang, C.-G. (deposition date: 2014-09-27, release date: 2016-04-06, Last modification date: 2024-02-28) |
Primary citation | Li, Q.,Huang, Y.,Liu, X.,Gan, J.,Chen, H.,Yang, C.G. Rhein Inhibits AlkB Repair Enzymes and Sensitizes Cells to Methylated DNA Damage. J.Biol.Chem., 291:11083-11093, 2016 Cited by PubMed: 27015802DOI: 10.1074/jbc.M115.711895 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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