4RFR

Complex structure of AlkB/rhein

4RFR の概要

関連するPDBエントリー3T4H
分子名称Alpha-ketoglutarate-dependent dioxygenase AlkB, 4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid, MANGANESE (II) ION, ... (4 entities in total)
機能のキーワードprotein-inhibitor complex, demethylation, alkb family, jellyroll fold, demethylase, nucleic acid binding, nucleus, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
由来する生物種Escherichia coli
ポリマー鎖数1
分子量合計22895.95
構造登録者
Li, Q.,Huang, Y.,Li, J.F.,Yang, C.-G. (登録日: 2014-09-27, 公開日: 2016-04-06, 最終更新日: 2016-09-28)
主引用文献
Li, Q.,Huang, Y.,Liu, X.,Gan, J.,Chen, H.,Yang, C.G.
Rhein Inhibits AlkB Repair Enzymes and Sensitizes Cells to Methylated DNA Damage.
J.Biol.Chem., 291:11083-11093, 2016
PubMed: 27015802 (主引用文献が同じPDBエントリー)
DOI: 10.1074/jbc.M115.711895
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (1.5 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.15130.5%0.6%4.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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