4RFD

Human carbonic anhydrase II in complex with 4-(4-sulfamoyl-phenoxy)-butylammonium

Summary for 4RFD

• Entry DOI: 10.2210/pdb4rfd/pdb
• Related: 4RFC
• Descriptor: Carbonic anhydrase 2, ZINC ION, 4-(4-sulfamoyl-phenoxy)-butylammonium, ... (5 entities in total)
• Functional Keywords: sulfonamide, carbonic anhydrase, antiglaucoma, o-(-aminoalkyl)-benzenesulfonamidess, lyase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm : P00918
• Total number of polymer chains: 1
• Total formula weight: 29904.11

Authors

Bozdag, M.,Pinard, M.A.,Carta, F.,Masini, E.,Scozzafava, A.,Mckenna, R.,Supuran, C.T. (deposition date: 2014-09-25, release date: 2015-04-15, Last modification date: 2024-02-28)

• Primary citation: Bozdag, M.,Pinard, M.,Carta, F.,Masini, E.,Scozzafava, A.,McKenna, R.,Supuran, C.T.; A class of 4-sulfamoylphenyl-omega-aminoalkyl ethers with effective carbonic anhydrase inhibitory action and antiglaucoma effects.; J.Med.Chem., 57:9673-9686, 2014; PubMed: 25358036; DOI: 10.1021/jm501497m

Experimental method

X-RAY DIFFRACTION (1.631 Å)