4RBP

Crystal structure of HIV neutralizing antibody 2G12 in complex with a bacterial oligosaccharide analog of mammalian oligomanose

4RBP の概要

• エントリーDOI: 10.2210/pdb4rbp/pdb
• 関連するPDBエントリー: 1OM3 1OP3 1OP5 1ZLS 1ZLU 1ZLV 1ZLW 2OQJ 3OAU 3OAY 3OAZ 3OB0
• 分子名称: Fab 2G12 light chain, Fab 2G12 heavy chain, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-5)-3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid, ... (5 entities in total)
• 機能のキーワード: immunoglobulin fold, hiv neutralizing, hiv-1 gp120, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 96929.81

構造登録者

Stanfield, R.L.,Wilson, I.A.,De Castro, C.,Marzaioli, A.M.,Pantophlet, R. (登録日: 2014-09-12, 公開日: 2014-11-26, 最終更新日: 2023-09-20)

• 主引用文献: Stanfield, R.L.,De Castro, C.,Marzaioli, A.M.,Wilson, I.A.,Pantophlet, R.; Crystal structure of the HIV neutralizing antibody 2G12 in complex with a bacterial oligosaccharide analog of mammalian oligomannose.; Glycobiology, 25:412-419, 2015; PubMed: 25380763; DOI: 10.1093/glycob/cwu123

実験手法

X-RAY DIFFRACTION (1.85 Å)