4RAK

Crystal structure of nuclear receptor subfamily 1, group h, member 2 (lxrb) complexed with partial agonist

4RAK の概要

• エントリーDOI: 10.2210/pdb4rak/pdb
• 分子名称: Oxysterols receptor LXR-beta, 1,4-BUTANEDIOL, 2-{2-[2-(2-chlorophenyl)propan-2-yl]-1-[3'-(methylsulfonyl)biphenyl-4-yl]-1H-imidazol-4-yl}propan-2-ol, ... (4 entities in total)
• 機能のキーワード: nhr, nr1h2, lxr-b, lxrb, unr, ner-i, rip15, ner, ligand binding domain, nuclear hormone receptor, rxr, transcription-agonist complex, transcription/agonist
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus : P55055
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 62374.19

構造登録者

Nanao, M. (登録日: 2014-09-10, 公開日: 2014-12-31, 最終更新日: 2024-02-28)

• 主引用文献: Kick, E.,Martin, R.,Xie, Y.,Flatt, B.,Schweiger, E.,Wang, T.L.,Busch, B.,Nyman, M.,Gu, X.H.,Yan, G.,Wagner, B.,Nanao, M.,Nguyen, L.,Stout, T.,Plonowski, A.,Schulman, I.,Ostrowski, J.,Kirchgessner, T.,Wexler, R.,Mohan, R.; Liver X Receptor (LXR) partial agonists: Biaryl pyrazoles and imidazoles displaying a preference for LXR beta.; Bioorg.Med.Chem.Lett., 25:372-377, 2015; PubMed: 25435151; DOI: 10.1016/j.bmcl.2014.11.029

実験手法

X-RAY DIFFRACTION (2.04 Å)