4RA0

An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axis

4RA0 の概要

• エントリーDOI: 10.2210/pdb4ra0/pdb
• 分子名称: Growth arrest-specific protein 6, Tyrosine-protein kinase receptor UFO, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• 機能のキーワード: axl, gas6, cancer, metastasis, signaling protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 132492.68

構造登録者

Kariolis, M.S.,Kapur, S.,Mathews, I.I.,Cochran, J.R. (登録日: 2014-09-09, 公開日: 2014-09-24, 最終更新日: 2023-09-20)

• 主引用文献: Kariolis, M.S.,Miao, Y.R.,Jones, D.S.,Kapur, S.,Mathews, I.I.,Giaccia, A.J.,Cochran, J.R.; An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axis.; Nat.Chem.Biol., 10:977-983, 2014; PubMed: 25242553; DOI: 10.1038/nchembio.1636

実験手法

X-RAY DIFFRACTION (3.07 Å)