4R9W

Crystal structure of platelet factor 4 complexed with fondaparinux

4R9W の概要

• エントリーDOI: 10.2210/pdb4r9w/pdb
• 関連するPDBエントリー: 4R97 4R9Y
• 関連するBIRD辞書のPRD_ID: PRD_900028
• 分子名称: Platelet factor 4, 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-3,6-di-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-methyl 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranoside (3 entities in total)
• 機能のキーワード: pf4, fondaparinux, cxc chemokine, platelet factor, glycosaminoglycan, platelet, cytokine
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 17072.65

構造登録者

Cai, Z.,Zhu, Z.,Liu, Q.,Greene, M.I. (登録日: 2014-09-08, 公開日: 2015-12-16, 最終更新日: 2020-07-29)

• 主引用文献: Cai, Z.,Yarovoi, S.V.,Zhu, Z.,Rauova, L.,Hayes, V.,Lebedeva, T.,Liu, Q.,Poncz, M.,Arepally, G.,Cines, D.B.,Greene, M.I.; Atomic description of the immune complex involved in heparin-induced thrombocytopenia.; Nat Commun, 6:8277-8277, 2015; PubMed: 26391892; DOI: 10.1038/ncomms9277

実験手法

X-RAY DIFFRACTION (2.5 Å)