4R6E

Human artd1 (parp1) - catalytic domain in complex with inhibitor niraparib

Summary for 4R6E

Entry DOI	10.2210/pdb4r6e/pdb
Related	4R5W 4UND 4UXB
Descriptor	Poly [ADP-ribose] polymerase 1, 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide, SULFATE ION, ... (5 entities in total)
Functional Keywords	adp-ribosylation, dna repair, adp-ribosyl transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Nucleus: P09874
Total number of polymer chains	4
Total formula weight	162741.88
Authors	Karlberg, T.,Thorsell, A.G.,Brock, J.,Schuler, H. (deposition date: 2014-08-25, release date: 2015-09-09, Last modification date: 2023-09-20)
Primary citation	Thorsell, A.G.,Ekblad, T.,Karlberg, T.,Low, M.,Pinto, A.F.,Tresaugues, L.,Moche, M.,Cohen, M.S.,Schuler, H. Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors. J.Med.Chem., 60:1262-1271, 2017 Cited by PubMed: 28001384 DOI: 10.1021/acs.jmedchem.6b00990 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation