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4R5X

Structure of the m1 alanylaminopeptidase from malaria complexed with a hydroxamic acid-based inhibitor

Summary for 4R5X
Entry DOI10.2210/pdb4r5x/pdb
Related3EBG 4R5T 4R5V 4R6T 4R76 4R7M
DescriptorM1 family aminopeptidase, ZINC ION, GLYCEROL, ... (7 entities in total)
Functional Keywordsprotease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourcePlasmodium falciparum FcB1/Columbia
Cellular locationCytoplasm: O96935
Total number of polymer chains1
Total formula weight106402.39
Authors
Drinkwater, N.,Mcgowan, S. (deposition date: 2014-08-22, release date: 2014-10-29, Last modification date: 2024-02-28)
Primary citationMistry, S.N.,Drinkwater, N.,Ruggeri, C.,Sivaraman, K.K.,Loganathan, S.,Fletcher, S.,Drag, M.,Paiardini, A.,Avery, V.M.,Scammells, P.J.,McGowan, S.
Two-Pronged Attack: Dual Inhibition of Plasmodium falciparum M1 and M17 Metalloaminopeptidases by a Novel Series of Hydroxamic Acid-Based Inhibitors.
J.Med.Chem., 57:9168-9183, 2014
Cited by
PubMed: 25299353
DOI: 10.1021/jm501323a
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.85 Å)
Structure validation

221051

数据于2024-06-12公开中

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