4R50

Crystal Structure of CNG mimicking NaK-ETPP mutant cocrystallized with Li+

Summary for 4R50

Entry DOI	10.2210/pdb4r50/pdb
Related	3K0D 3K0G 4R6Z
Descriptor	Potassium channel protein, (4S)-2-METHYL-2,4-PENTANEDIOL, GLYCINE, ... (4 entities in total)
Functional Keywords	alpha helical membrane protein, chimera channel, transport protein
Biological source	Bacillus cereus ATCC 14579
Total number of polymer chains	2
Total formula weight	21821.69
Authors	De March, M.,Napolitano, L.M.R.,Onesti, S. (deposition date: 2014-08-20, release date: 2015-07-01, Last modification date: 2023-09-20)
Primary citation	Napolitano, L.M.,Bisha, I.,De March, M.,Marchesi, A.,Arcangeletti, M.,Demitri, N.,Mazzolini, M.,Rodriguez, A.,Magistrato, A.,Onesti, S.,Laio, A.,Torre, V. A structural, functional, and computational analysis suggests pore flexibility as the base for the poor selectivity of CNG channels. Proc.Natl.Acad.Sci.USA, 112:E3619-E3628, 2015 Cited by PubMed: 26100907 DOI: 10.1073/pnas.1503334112 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.85 Å)

Structure validation