4R4H

Crystal structure of non-neutralizing, A32-like antibody 2.2c in complex with HIV-1 Env gp120

Summary for 4R4H

• Entry DOI: 10.2210/pdb4r4h/pdb
• Related: 4R4B 4R4F 4R4N
• Descriptor: HIV-1 Env gp120, T-cell surface glycoprotein CD4, Antibody 2.2c, Light chain, ... (5 entities in total)
• Functional Keywords: hiv-1 attachment glycoprotein gp120, viral protein-immune system-inhibitor complex, viral protein/immune system/inhibitor
• Biological source: Human immunodeficiency virus 1 (HIV-1); More
• Total number of polymer chains: 4
• Total formula weight: 117088.30

Authors

Mclellan, J.,Acharya, P.,Huang, C.-C.,Kwong, P.D. (deposition date: 2014-08-19, release date: 2014-09-17, Last modification date: 2020-07-29)

• Primary citation: Acharya, P.,Tolbert, W.D.,Gohain, N.,Wu, X.,Yu, L.,Liu, T.,Huang, W.,Huang, C.C.,Kwon, Y.D.,Louder, R.K.,Luongo, T.S.,McLellan, J.S.,Pancera, M.,Yang, Y.,Zhang, B.,Flinko, R.,Foulke, J.S.,Sajadi, M.M.,Kamin-Lewis, R.,Robinson, J.E.,Martin, L.,Kwong, P.D.,Guan, Y.,DeVico, A.L.,Lewis, G.K.,Pazgier, M.; Structural Definition of an Antibody-Dependent Cellular Cytotoxicity Response Implicated in Reduced Risk for HIV-1 Infection.; J.Virol., 88:12895-12906, 2014; PubMed: 25165110; DOI: 10.1128/JVI.02194-14

Experimental method

X-RAY DIFFRACTION (4.28 Å)