4R3N
Crystal structure of the ternary complex of sp-ASADH with NADP and 1,2,3-Benzenetricarboxylic acid
Summary for 4R3N
Entry DOI | 10.2210/pdb4r3n/pdb |
Descriptor | Aspartate-semialdehyde dehydrogenase, SODIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (7 entities in total) |
Functional Keywords | protein-nadp-ligand complex, dehydrogenase, oxidoreductase, nadp binding |
Biological source | Streptococcus pneumoniae |
Total number of polymer chains | 2 |
Total formula weight | 83343.03 |
Authors | Pavlovsky, A.G.,Viola, R.E. (deposition date: 2014-08-16, release date: 2014-12-10, Last modification date: 2024-02-28) |
Primary citation | Pavlovsky, A.G.,Thangavelu, B.,Bhansali, P.,Viola, R.E. A cautionary tale of structure-guided inhibitor development against an essential enzyme in the aspartate-biosynthetic pathway. Acta Crystallogr.,Sect.D, 70:3244-3252, 2014 Cited by PubMed: 25478842DOI: 10.1107/S1399004714023979 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.35 Å) |
Structure validation
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