4R02
yCP in complex with BSc4999 (alpha-Keto Phenylamide)
Summary for 4R02
Entry DOI | 10.2210/pdb4r02/pdb |
Related | 1RYP 4QTR 4QUX 4QUY 4QV0 4QV1 4QV3 4QV4 4QV5 4QV6 4QV7 4QV8 4QV9 4QVL 4QVM 4QVN 4QVP 4QVQ 4QWR 4QWS 4QWX 4QZ0 4QZ1 4QZ2 4QZ3 4QZ5 4QZ6 4QZX 4QZZ |
Related PRD ID | PRD_001244 |
Descriptor | Proteasome subunit alpha type-2, Proteasome subunit beta type-4, Proteasome subunit beta type-5, ... (17 entities in total) |
Functional Keywords | cancer, proteasome, drug development, binding analysis, reversible covalent ligand, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Saccharomyces cerevisiae (Baker's yeast) More |
Cellular location | Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451 |
Total number of polymer chains | 28 |
Total formula weight | 732567.75 |
Authors | Voss, C.,Scholz, C.,Knorr, S.,Beck, P.,Stein, M.,Zall, A.,Kuckelkorn, U.,Kloetzel, P.-M.,Groll, M.,Hamacher, K.,Schmidt, B. (deposition date: 2014-07-29, release date: 2014-08-13, Last modification date: 2023-09-20) |
Primary citation | Voss, C.,Scholz, C.,Knorr, S.,Beck, P.,Stein, M.L.,Zall, A.,Kuckelkorn, U.,Kloetzel, P.M.,Groll, M.,Hamacher, K.,Schmidt, B. alpha-Keto Phenylamides as P1'-Extended Proteasome Inhibitors. Chemmedchem, 9:2557-2564, 2014 Cited by PubMed: 25087721DOI: 10.1002/cmdc.201402244 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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