4QZS

Crystal structure of the first bromodomain of human 3-fluoro tyrosine-labeled brd4 in complex with jq1

Summary for 4QZS

Entry DOI	10.2210/pdb4qzs/pdb
Descriptor	Bromodomain-containing protein 4, (6S)-6-(2-tert-butoxy-2-oxoethyl)-4-(4-chlorophenyl)-2,3,9-trimethyl-6,7-dihydrothieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-10-ium, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	cap, mcap, protein binding-inhibitor complex, mitotic chromosome associated protein, cell cycle, inhibitor, transcription
Biological source	Homo sapiens (human)
Cellular location	Nucleus: O60885
Total number of polymer chains	1
Total formula weight	15842.89
Authors	Ember, S.W.,Schonbrunn, E. (deposition date: 2014-07-28, release date: 2014-10-29, Last modification date: 2023-09-20)
Primary citation	Mishra, N.K.,Urick, A.K.,Ember, S.W.,Schonbrunn, E.,Pomerantz, W.C. Fluorinated aromatic amino acids are sensitive (19)f NMR probes for bromodomain-ligand interactions. Acs Chem.Biol., 9:2755-2760, 2014 Cited by PubMed: 25290579 DOI: 10.1021/cb5007344 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.45 Å)

Structure validation