4QZ6

yCP beta5-A49T-A50V double mutant in complex with the epoxyketone inhibitor ONX 0914

Summary for 4QZ6

• Entry DOI: 10.2210/pdb4qz6/pdb
• Related: 1RYP
• Related PRD ID: PRD_000991
• Descriptor: Proteasome subunit alpha type-2, Proteasome subunit beta type-4, Proteasome subunit beta type-5, ... (19 entities in total)
• Functional Keywords: cancer, proteasome, bortezomib, drug resistance, binding analysis, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Saccharomyces cerevisiae (Baker's yeast); More
• Cellular location: Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451
• Total number of polymer chains: 28
• Total formula weight: 735330.97

Authors

Huber, E.M.,Heinemeyer, W.,Groll, M. (deposition date: 2014-07-27, release date: 2015-02-04, Last modification date: 2023-09-20)

• Primary citation: Huber, E.M.,Heinemeyer, W.,Groll, M.; Bortezomib-Resistant Mutant Proteasomes: Structural and Biochemical Evaluation with Carfilzomib and ONX 0914.; Structure, 23:407-417, 2015; PubMed: 25599643; DOI: 10.1016/j.str.2014.11.019

Experimental method

X-RAY DIFFRACTION (2.9 Å)