4QYK

Crystal structure of a canine parvovirus variant

This is a non-PDB format compatible entry.

Summary for 4QYK

• Entry DOI: 10.2210/pdb4qyk/pdb
• Descriptor: Capsid protein VP1, MAGNESIUM ION (2 entities in total)
• Functional Keywords: capsid protein, virus
• Biological source: Feline panleukopenia virus (FPV)
• Total number of polymer chains: 30
• Total formula weight: 1943095.92

Authors

Lukk, T.,Organtini, L.J.,Hafenstein, S.U. (deposition date: 2014-07-24, release date: 2014-12-10, Last modification date: 2024-10-30)

Primary citation

Organtini, L.J.,Allison, A.B.,Lukk, T.,Parrish, C.R.,Hafenstein, S.
Global Displacement of Canine Parvovirus by a Host-Adapted Variant: Structural Comparison between Pandemic Viruses with Distinct Host Ranges.
J.Virol., 89:1909-1912, 2015

PubMed Abstract: Canine parvovirus type 2 (CPV-2) emerged in 1978 and spread worldwide within 2 years. Subsequently, CPV-2 was completely replaced by the variant CPV-2a, which is characterized by four specific capsid (VP2) mutations. The X-ray crystal structure of the CPV-2a capsid shows that each mutation confers small local changes. The loss of a hydrogen bond and introduction of a glycine residue likely introduce flexibility to sites that control interactions with the host receptor, antibodies, and sialic acids.

PubMed: 25410876
DOI: 10.1128/JVI.02611-14

Experimental method

X-RAY DIFFRACTION (3.5 Å)