4QYH
CHK1 kinase domain in complex with diazacarbazole GNE-783
Summary for 4QYH
| Entry DOI | 10.2210/pdb4qyh/pdb |
| Related | 4QYE 4QYF 4QYG |
| Descriptor | Serine/threonine-protein kinase Chk1, 3-[4-(4-methylpiperazin-1-yl)phenyl]-9H-pyrrolo[2,3-b:5,4-c']dipyridine-6-carbonitrile (3 entities in total) |
| Functional Keywords | protein kinase, phosphotransfer catalyst, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Nucleus: O14757 |
| Total number of polymer chains | 2 |
| Total formula weight | 69147.27 |
| Authors | Wiesmann, C.,Wu, P. (deposition date: 2014-07-24, release date: 2014-12-17, Last modification date: 2024-02-28) |
| Primary citation | Gazzard, L.,Appleton, B.,Chapman, K.,Chen, H.,Clark, K.,Drobnick, J.,Goodacre, S.,Halladay, J.,Lyssikatos, J.,Schmidt, S.,Sideris, S.,Wiesmann, C.,Williams, K.,Wu, P.,Yen, I.,Malek, S. Discovery of the 1,7-diazacarbazole class of inhibitors of checkpoint kinase 1. Bioorg.Med.Chem.Lett., 24:5704-5709, 2014 Cited by PubMed: 25453805DOI: 10.1016/j.bmcl.2014.10.063 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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